研 究 業 績

 2004年以降のものを掲載します。それ以前の主要な論文に関しては 研究内容の所にそれぞれ掲載していますので、そちらを見てください。

2012

A. Yoshida, D. Wei, W. Nomura, S. Izawa and Y. inoue (2012)
Reduction of Glucose Uptake through Inhibition of Hexose Transporters and Enhancement of Their Endocytosis by Methylglyoxal in Saccharomyces cerevisiae. J. Biol. Chem. 287, 701-711[PubMed]

2011

T. Akao, I. Yashiro, A. Hosoyama, H. Kitagaki, H. Horikawa, D. Watanabe, R. Akada, Y. Ando, S. Harashima, T. Inoue, Y. Inoue, S. Kajiwara, K. Kitamoto, N. Kitamoto, O. Kobayashi, S. Kuhara, T. Masubuchi, H. Mizoguchi, Y. Nakao, A. Nakazato, M. Namise, T. Oba, T. Ogata, A. Ohta, M. Sato, S. Shibasaki, Y. Takatsume, S. Tanimoto, H. Tsuboi, A. Nishimura, K. Yoda, T. Ishikawa, K. Iwashita, N. Fujita and H. Shimoi (2011)
Whole-Genome Sequencing of Sake Yeast Saccharomyces cerevisiae Kyokai no. 7. DNA Res. 18, 423-434 [PubMed]

Y. Ukai, T. Kishimoto, T. Ohdate, S. Izawa and Y. Inoue (2011)
Glutathione peroxidase 2 in Saccharomyces cerevisiae is distributed in mitochondria and involved in sporulation. Biochem. Biophys. Res. Commun. 411, 580-585 [PubMed]

H. M. Semchyshyn, O. B. Abrat, J. Miedzobrodzki, Y. Inoue and V. I. Lushchak (2011)
Acetate but not propionate induces oxidative stress in bakers' yeast Saccharomyces cerevisiae. Redox Rep. 16, 15-23 [PubMed]

Y. Inoue, K. Maeta and W. Nomura (2011)
Glyoxalase system in yeasts: Structure, function, and physiology. Semin. Cell Dev. Biol. 22, 278-284 [PubMed]

K. Ikeda, S. Kitagawa, T. Tada, H. Iefuji, Y. Inoue and S. Izawa (2011)
Modification of yeast characteristics by soy peptides: cultivation with soy peptides represses the formation of lipid bodies. Appl. Microbiol. Biotechnol. 89, 1971-1977 [PubMed]

2010

S. Izawa, K. Ikeda, T. Miki, Y. Wakai and Y. Inoue (2010)
Vacuolar morphology of Saccharomyces cerevisiae during the process of wine making and Japanese sake brewing. Appl. Microbiol. Biotechnol. 88, 277-282 [PubMed]

O. V. Lushchak, Y. Inoue and V. I. Lushchak (2010)
Regulatory protein Yap1 is involved in response of yeast Saccharomyces cerevisiae to nitrosative stress. Biochemistry (Mosc). 75, 629-635 [PubMed]

T. Ohdate, K. Kita and Y. Inoue (2010)
Kinetics and redox regulation of Gpx1, an atypical 2-Cys peroxiredoxin, in Saccharomyces cerevisiae. FEMS Yeast Res. 10, 787-790 [PubMed]

W. Nomura, K. Maeta, K. Kita, S. Izawa and Y. Inoue (2010)
Methylglyoxal activates Gcn2 to phosphorylate eIF2α independently of the TOR pathway in Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 86, 1887-1894 [PubMed]

Y. Takatsume, T. Ohdate, K. Maeta, W. Nomura, S. Izawa and Y. Inoue (2010)
Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca2+ in Saccharomyces cerevisiae. Biochem. J. 427, 275-287[PubMed]
Equally contributed

T. Ohdate, S. Izawa, K. Kita and Y. Inoue (2010)
Regulatory mechanism for expression of GPX1 in response to glucose starvation and Ca2+ in Saccharomyces cerevisiae: Involvement of Snf1 and Ras/cAMP pathway in Ca2+ signaling. Genes Cells 15, 59-75 [PubMed]

2009

O.V. Lushchak, N.Z. Nykorak, T. Ohdate, Y. Inoue and V.I. Lushchak (2009)
Inactivation of genes encoding superoxide dismutase modifies yeast response to S-nitrosoglutathione-induced stress. Biochemistry(Mosc). 74, 445-451 [PubMed]

S. Izawa and Y. Inoue (2009)
Post-transcriptional regulation of gene expression in yeast under ethanol stress. Biotecnol. Appl. Biochem. 53, 93-99 [PubMed]

2008

W. Nomura, K. Maeta, K. Kita, S. Izawa and Y. Inoue (2008)
Role of Gcn4 for adaptation to methylglyoxal in Saccharomyces cerevisiae: Methylglyoxal attenuates protein synthesis through phosphorylation of eIF2α. Biochem. Biophys. Res. Commun. 376, 738-42 [PubMed]

S. Izawa, T. Kita, K. Ikeda and Y. Inoue (2008)
Heat shock and ethanol stress provoke distinctly different responses in 3'-processing and nuclear export of HSP mRNA in Saccharomyces cerevisiae. Biochem. J. 414, 111-119 [PubMed]

2007

Y. Takeuchi, W. Nomura, T. Ohdate, S. Tamasu, H. Masutani, K. Murata, S. Izawa, J. Yodoi and Y. Inoue (2007) Release of thioredoxin from Saccharomyces cerevisiae with environmental stimuli: solubilization of thioredoxin with ethanol. Appl. Microbiol. Biotechnol. 75, 1393-1399 [PubMed]

S. Izawa, K. Ikeda, N. Takahashi and Y. Inoue (2007) Improvement of tolerance to freeze-thaw stress of baker's yeast by cultivation with soy peptides. Appl. Microbiol. Biotechnol. 75, 533-538 [PubMed]

Y. Inoue, W. Nomura, Y. Takeuchi, T. Ohdate, S. Tamasu, A. Kitaoka, Y. Kiyokawa, H. Masutani, K. Murata, Y. Wakai, S. Izawa and J. Yodoi (2007) Efficient extraction of thioredoxin from Saccharomyces cerevisiae with ethanol. Appl. Environ. Microbiol. 73, 1672-1675 [PubMed]

K. Maeta, W. Nomura, Y. Takatsume, S. Izawa and Y. Inoue (2007) Green tea polyphenols function as prooxidants to activate oxidative stress-responsive transcription factors in yeasts. Appl. Environ. Microbiol. 73, 572-580 [PubMed]

S. Izawa, K. Ikeda, T. Ohdate and Y. Inoue. (2007) Msn2p/Msn4p-activation is essential for the recovery from freezing stress in yeast. Biochem. Biophys. Res. Commun. 352, 750-755 [PubMed]

S. Izawa, T. Kita, K. Ikeda, T. Miki and Y. Inoue (2007) Formation of the cytoplasmic P-bodies in sake yeast during Japanese sake brewing and wine making. Biosci. Biotechnol. Biochem. 71, 2800-2807 [PubMed]

Y. Takatsume, S. Izawa and Y. Inoue (2007) Modulation of Spc1 stress-activated protein kinase activity by methylglyoxal through inhibition of protein phosphatase in the fission yeast Schizosaccharomyces pombe. Biochem. Biophys. Res. Commun. 363, 942-947 [PubMed]

2006

S. Izawa, K. Ikeda, T. Kita and Y. Inoue. (2006) Asr1, an alcohol-responsive factor of Saccharomyces cerevisiae, is dispensable for alcoholic fermentation. Appl. Microbiol. Biotechnol. 72, 560-565[PubMed]

Y. Takatsume, S. Izawa and Y. Inoue. (2006) Methylglyoxal as a signal initiator for activation of the stress-activated protein kinase cascade in the fission yeast Schizosaccharomyces pombe. J. Biol. Chem. 281, 9086-9092[PubMed]

前田和宏、井沢真吾、井上善晴.(2006) 酵母に見いだされたシステイン残基の新奇な修飾を介したシグナル伝達〜解糖系由来のメチルグリオキサールが引き起こすシグナル伝達経路の活性化〜.化学と生物、44, 361-363

井沢真吾、井上善晴.酒類醸造における酵母のアルコール耐性と応答、「発酵・醸造食品の最新技術と機能性」シーエムシー出版

2005

T. Tanaka, S. Izawa and Y. Inoue (2005) GPX2, encoding a phospholipid hydroperoxide glutathione peroxidase homologue, codes for an atypical 2-Cys peroxiredoxin in Saccharomyces cerevisiae. J. Biol. Chem. 280, 42078-42087[PubMed]

S. Izawa, R. Takemura, K. Ikeda, K. Fukuda, Y. Wakai and Y. Inoue (2005) Characterization of Rat8-localization and mRNA export in Saccharomyces cerevisiae during Japanese Sake brewing. Appl. Microbiol. Biotechnol. 69, 86-91 [PubMed]

A. Zuin, A. P. Vivancos, M. Sanso, Y. Takatsume, J. Ayte, Y. Inoue and E. Hidalgo (2005) The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe. J. Biol. Chem. 280, 36708-3671 [PubMed]

S. Izawa, R. Takemura, T. Miki and Y. Inoue (2005) Characterization of the export of bulk poly (A)+ mRNA in Saccharomyces cerevisiae during wine-making process. Appl. Environ. Microbiol. 71, 2179-2182[PubMed]

Y. Takatsume, S. Izawa and Y. Inoue (2005) Unique regulation of glyoxalase I activity during osmotic stress response in the fission yeast Schizosaccharomyces pombe: neither the mRNA nor protein level of glyoxalase I increases under conditions that enhance its activity. Arch. Microbiol. 183, 224-227[PubMed]

K. Maeta, K. Mori, Y. Takatsume, S. Izawa and Y. Inoue (2005) Diagnosis of cell death induced by methylglyoxal, a metabolite derived from glycolysis, in Saccharomyces cerevisiae. FEMS Microbiol. Lett. 243, 87-92 [PubMed]

K. Maeta, S. Izawa and Y. Inoue (2005) Methylglyoxal, a metabolite derived from glycolysis, functions as a signal initiator of the high osmolarity glycerol-mitogen-activated protein kinase cascade and calcineurin/Crz1-mediated pathway in Saccharomyces cerevisiae. J. Biol. Chem. 280, 253-260 [PubMed]

Y. Takatsume, K. Maeta, S. Izawa and Y. Inoue (2005) Enrichment of yeast thioredoxin by green tea extract through activation of Yap1 transcription factor in Saccharomyces cerevisiae. J. Agric. Food. Chem. 53, 332-337 [PubMed]

W. Bi, Y. Inai, N. Shiraishi, K. Maeta Y. Takatsume, Y. Inoue and M. Nishikimi (2005) Cytosolic proteins as principal copper buffer in an early response to copper by yeast cells. J. Clin. Biochem. Nutr. 36, 19-27 [J-STAGE]

井沢真吾、竹村玲子、井上善晴. mRNA核外輸送段階におけるストレス応答 清酒醸造過程における酵母の特異なエタノール応答. 化学と生物 43, 278-280, 2005

井沢真吾 酵母とエタノールストレス. 日本醸造協会誌 100, 305-309, 2005

2004

S. Izawa, M. Sato, K. Yokoigawa and Y. Inoue (2004) Intracellular glycerol influences resistance to freeze stress in Saccharomyces cerevisiae: analysis of a quadruple mutant in glycerol dehydrogenase genes and glycerol-enriched cells. Appl. Microbiol. Biotechnol. 66,108-114.[PubMed]

S. Izawa, K. Ikeda, K. Maeta and Y. Inoue (2004) Deficiency in the glycerol channel Fps1p confers increased freeze tolerance to yeast cells: application of the fps1Δ mutant to frozen dough technology. Appl. Microbiol. Biotechnol. 66,303-305. [PubMed]

S. Izawa, R. Takemura and Y. Inoue (2004) Gle2p is essential to induce adaptation of the export of bulk poly (A)+ mRNA to heat shock in Saccharomyces cerevisiae. J. Biol. Chem. 279, 35469-35478 [PubMed]

K. Maeta, S. Izawa, S. Okazaki, S. Kuge and Y. Inoue (2004) Activity of the Yap1 transcription factor in Saccharomyces cerevisiae is modulated by methylglyoxal, a metabolite derived from glycolysis. Mol. Cell. Biol. 24, 8753-8764 [PubMed]

R. Takemura, Y. Inoue and S. Izawa (2004) Stress response in the yeast mRNA export factor: reversible change in the localization of Rat8p is caused by ethanol stress but not heat shock. J. Cell Sci. 117, 4189-4197 [PubMed]

S. Izawa, N. Kuroki and Y. Inoue (2004) Nuclear thioredoxin peroxidase Dot5 in Saccharomyces cerevisiae: roles in oxidative stress response and disruption of telomeric silencing. Appl. Microbiol. Biotechnol. 64, 120 -124 [PubMed]

S. Izawa and Y. Inoue (2004) A screening system for antioxidants using thioredoxin-deficient yeast: discovery of thermostable antioxidant activity from Agaricus blazei Murill. Appl. Microbiol. Biotechnol. 64, 537 -542 [PubMed]

Y. Takatsume, S. Izawa and Y. Inoue (2004) Identification of thermostable glyoxalase I in the fission yeast Schizosaccharomyces pombe. Arch. Microbiol. 181, 371-377[PubMed]

D. Tsuzi, K. Maeta, Y. Takatsume, S. Izawa and Y. Inoue (2004) Regulation of the yeast phospholipid hydroperoxide glutathione peroxidase GPX2 by oxidative stress is mediated by Yap1 and Skn7. FEBS Letters, 565, 148-154 [PubMed]

D. Tsuzi, K. Maeta, Y. Takatsume, S. Izawa and Y. Inoue (2004) Distinct regulatory mechanism of yeast GPX2 encoding phospholipids hydroperoxide glutathione peroxidase by oxidative stress and a calcineurin/Crz1-mediated Ca2+ signaling pathway. FEBS Letters, 569, 301-306 [PubMed]

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